Microtubules form a highly dynamic filament network in all eukaryotic cells. Individual microtubules grow by tubulin dimer subunit addition and frequently switch between phases of growth and shortening. These unique dynamics are powered by GTP hydrolysis and drive microtubule network remodeling, which is central to eukaryotic cell biology and morphogenesis. Yet, our knowledge of the molecular events at growing microtubule ends remains incomplete. Here, recent ultrastructural, biochemical and cell biological data are integrated to develop a realistic model of growing microtubule (...) ends comprised of structurally distinct but biochemically overlapping zones. Proteins that recognize microtubule lattice conformations associated with specific tubulin guanosine nucleotide states may independently control major structural transitions at growing microtubule ends. A model is proposed in which tubulin dimer addition and subsequent closure of the MT wall are optimized in cells to achieve rapid physiological microtubule growth. (shrink)

PurposeThe aim of the research described was to identify reasons for differences between discourses on electronic voting in the UK and The Netherlands, from a qualitative point of view.Design/methodology/approachFrom both countries, eight e‐voting experts were interviewed on their expectations, risk estimations, cooperation and learning experiences. The design was based on the theory of strategic niche management. A qualitative analysis of the data was performed to refine the main variables and identify connections.FindingsThe results show that differences in these variables can partly (...) explain the variations in the embedding of e‐voting in the two countries, from a qualitative point of view. Key differences include the goals of introducing e‐voting, concerns in relation to verifiability and authenticity, the role of the Electoral Commissions and a focus on learning versus a focus on phased introduction.Research limitations/implicationsThe current study was limited to two countries. More empirical data can reveal other relevant subvariables, and contribute to a framework that can improve our understanding of the challenges of electronic voting.Originality/valueThis study shows the context‐dependent character of discussions on information security. It can be informative for actors involved in e‐voting in the UK and The Netherlands, and other countries using or considering electronic voting. (shrink)

This chapter is on when and how formalization and model building contribute to theory construction in methodological individualism. It shows that formalization is not always needed but can sometimes be useful for making assumptions explicit and for deriving implications that would appear out of reach of, or even go counter to, informal reasoning. The chapter focuses on examples from different theoretical approaches and research fields, including meanwhile ‘classic’ as well as more recent contributions. We sketch both insights that do not (...) require elaborate formalization as well as implications that do require some degree of formalization. The exposition itself is largely informal. (shrink)

Equipped with the ultimate query answering system, computers would finally be in a position to address all our information needs in a natural way. In this paper, we describe how Language and Computing nv (L&C), a developer of ontology-based natural language understanding systems for the healthcare domain, is working towards the ultimate Question Answering (QA) System for healthcare workers. L&C’s company strategy in this area is to design in a step-by-step fashion the essential components of such a system, each component (...) being designed to solve some one part of the total problem and at the same time reflect well-defined needs on the prat of our customers. We compare our strategy with the research roadmap proposed by the Question Answering Committee of the National Institute of Standards and Technology (NIST), paying special attention to the role of ontology. (shrink)

As a contribution to the emerging field of corporate social responsibility cognition, this article reports on the findings of an exploratory study that compares SME owner–managers’ mental models with regard to CSR and related concepts across six European countries. Utilising Repertory Grid Technique, we found that the SME owner–managers’ mental models show a few commonalities as well as a number of differences across the different country samples. We interpret those differences by linking individual cognition to macro-environmental variables, such as language, (...) national traditions and dissemination mechanisms. The results of our exploratory study show that nationality matters but that classifications of countries as found in the comparative capitalism literature do not exactly mirror national differences in CSR cognition and that these classifications need further differentiation. The findings from our study raise questions on the universality of cognition of academic management concepts and warn that promotion of responsible business practice should not rely on the use of unmediated US American management terminology. (shrink)

The vast majority of empirical research on stakeholder management has traditionally focused on multinational corporations. Only in recent years, scholars have begun to pay attention to the stakeholder management concept in relation to small- and medium-sized enterprises (SMEs). The few existing studies in this area, however, discuss SMEs as a context free category or remain focused on single country analysis. This cross-national empirical research investigates SME owner—managers' perceptions of stakeholder management in six European countries. The comparative analysis is followed by (...) a discussion of how institutional, cultural and linguistic contexts can influence owner—managers' sensemaking of stakeholder management. Our study questions the universality of specific management terms and proposes that more attention should be paid to the institutional, cultural and linguistic environments that shape economic activity in different parts of Europe. (shrink)

The vast majority of empirical research on stakeholder management has traditionally focused on multinational corporations. Only in recent years, scholars have begun to pay attention to the stakeholder management concept in relation to small- and medium-sized enterprises (SMEs). The few existing studies in this area, however, discuss SMEs as a context free category or remain focused on single country analysis. This cross-national empirical research investigates SME owner-managers' perceptions of stakeholder management in six European countries. The comparative analysis is followed by (...) a discussion of how institutional, cultural and linguistic contexts can influence owner-managers' sensemaking of stakeholder management. Our study questions the universality of specific management terms and proposes that more attention should be paid to the institutional, cultural and linguistic environments that shape economic activity in different parts of Europe. (shrink)

Big data biology—bioinformatics, computational biology, systems biology (including ‘omics’), and synthetic biology—raises a number of issues for the philosophy of science. This article deals with several such: Is data-intensive biology a new kind of science, presumably post-reductionistic? To what extent is big data biology data-driven? Can data ‘speak for themselves?’ I discuss these issues by way of a reflection on Carl Woese’s worry that “a society that permits biology to become an engineering discipline, that allows that science to slip into (...) the role of changing the living world without trying to understand it, is a danger to itself.” And I argue that scientific perspectivism, a philosophical stance represented prominently by Giere, Van Fraassen, and Wimsatt, according to which science cannot as a matter of principle transcend our human perspective, provides the best resources currently at our disposal to tackle many of the philosophical issues implied in the modeling of complex, multilevel/multiscale phenomena. (shrink)

Peer review is a widely accepted instrument for raising the quality of science. Peer review limits the enormous unstructured influx of information and the sheer amount of dubious data, which in its absence would plunge science into chaos. In particular, peer review offers the benefit of eliminating papers that suffer from poor craftsmanship or methodological shortcomings, especially in the experimental sciences. However, we believe that peer review is not always appropriate for the evaluation of controversial hypothetical science. We argue that (...) the process of peer review can be prone to bias towards ideas that affirm the prior convictions of reviewers and against innovation and radical new ideas. Innovative hypotheses are thus highly vulnerable to being “filtered out” or made to accord with conventional wisdom by the peer review process. Consequently, having introduced peer review, the Elsevier journal Medical Hypotheses may be unable to continue its tradition as a radical journal allowing discussion of improbable or unconventional ideas. Hence we conclude by asking the publisher to consider re-introducing the system of editorial review to Medical Hypotheses. (shrink)

In a recent article published in this journal, Kris McDaniel proposes a variant of Peter van Inwagen’s argument against the principle of sufficient reason that makes crucial use of plural grounding. In this response paper I object to McDaniel’s argument. I argue that there is no notion of plural grounding available that is both irreflexive in the sense required for the argument to go through and general enough to formulate the principle of sufficient reason as proposed by McDaniel.

Recent years saw the rise of an interest in the roles and significance of thought experiments in different areas of human thinking. Heisenberg's gamma ray microscope is no doubt one of the most famous examples of a thought experiment in physics. Nevertheless, this particular thought experiment has not received much detailed attention in the philosophical literature on thought experiments up to date, maybe because of its often claimed inadequacies. In this paper, I try to do two things: to provide an (...) interesting interpretation of the roles played by Heisenberg's gamma ray microscope in interpreting quantum mechanics – partly based on Thomas Kuhn’s views on the function of thought experiments – and to contribute to the ongoing discussions on the roles and significance of thought experiments in physics. (shrink)

Toen de jonge Duitse natuurkundige Werner Heisenberg in 1925 ontdekte dat het gedrag van deeltjes op atomair niveau onbepaalbaar is, ontketende hij een wetenschappelijke revolutie die het moderne wereldbeeld op zijn kop zette. Tot het moment van Heisenbergs ontdekking dachten wetenschappers dat alles meetbaar was en leek het een kwestie van tijd voordat de mens de natuur geheel en al zou hebben doorgrond. Met de quantumfysica, waarvoor Heisenberg de grondslag legde, kwam aan dit optimisme een abrupt einde. Er bleek (...) een kloof te gapen tussen onze waarneming en de dynamiek waar alles uit voortkomt.00In?Quantum, de oerknal en God? onderneemt Maarten van Buuren een filosofische verkenning van de consequenties van Werner Heisenbergs ontdekking. Dat brengt Van Buuren tot een nieuw inzicht over de oorsprong van de dingen.?God is Natuur? stelde Baruch Spinoza in de 17e eeuw, maar met de opkomst van de moderne natuurkunde in de 18e en 19e eeuw raakte de natuur haar goddelijke status kwijt. Volgens Van Buuren keert God dankzij de quantumfysica terug als alomvattende kiemkracht in de Natuur. Het idee dat alle natuurprocessen gehoorzamen aan de wet van afkoeling en verval moet volgens hem worden herzien. Aan afkoeling en verval gaat een dynamische impuls vooraf waaruit alle dingen ontstaan en die de energie levert voor alles wat groeit en bloeit.?Vormkracht? is de motor van het universum.0. (shrink)

This paper focuses on a running dispute between Werner Callebaut’s naturalistic view and Filip Kolen and Gertrudis Van de Vijver’s transcendentalist view on the nature of philosophy of biology and the relation of this discipline to biological sciences. It is argued that, despite differences in opinion, both positions agree that philosophy of biology’s ultimate goal is to ‘move’ biology or at least be ‘meaningful’ to it. In order to make this goal clear and effective, more is needed than a (...) polarizing debate which hardly touches upon biology. Therefore, a redirection in discussion is suggested towards a reflection on the possibilities of incorporating philosophy in interdisciplinary research, and on finding concrete research questions which are of interest both to the philosopher and to the biologist. (shrink)

Dans une lettre du 25 octobre 1971 à Werner Hofmann, l’interrogeant sur la proximité de sa pensée avec celle du philosophe Ernst Cassirer, Claude Lévi-Strauss se justifie ainsi : « J’ai très peu fréquenté l’œuvre de Cassirer et je ne crois donc pas avoir été influencé par elle. Mais il y a deux ans environ, j’ai pris connaissance d’un article de lui, publié en français dans le Journal de Psychologie,...

The goal of referent tracking is to create an ever-growing pool of data relating to the entities existing in concrete spatiotemporal reality. In the context of Electronic Healthcare Records (EHRs) the relevant concrete entities are not only particular patients but also their parts, diseases, therapies, lesions, and so forth, insofar as these are salient to diagnosis and treatment. Within a referent tracking system, all such entities are referred to directly and explicitly, something which cannot be achieved when familiar concept-based systems (...) are used in what is called “clinical coding”. In this paper we describe the components of a referent tracking system in an informal way and we outline the procedures that would have to be followed by healthcare personnel in using such a system. We argue that the referent tracking paradigm can be introduced with only minor – though nevertheless ontologically important – technical changes to existing EHR infrastructures, but that it will require a radically different mindset on the part of those involved in clinical coding and terminology development from that which has prevailed hitherto. (shrink)

While classifications of mental disorders have existed for over one hundred years, it still remains unspecified what terms such as 'mental disorder', 'disease' and 'illness' might actually denote. While ontologies have been called in aid to address this shortfall since the GALEN project of the early 1990s, most attempts thus far have sought to provide a formal description of the structure of some pre-existing terminology or classification, rather than of the corresponding structures and processes on the side of the patient. (...) We here present a view of mental disease that is based on ontological realism and which follows the principles embodied in Basic Formal Ontology and in the application of BFO in the Ontology of General Medical Science. We analyzed statements about what counts as a mental disease provided in the research agenda for the DSM-V, and in Pies' model. The results were used to assess whether the representational units of BFO and OGMS were adequate as foundations for a formal representation of the entities in reality that these statements attempt to describe. We then analyzed the representational units specific to mental disease and provided corresponding definitions. Our key contributions lie in the identification of confusions and conflations in the existing terminology of mental disease and in providing what we believe is a framework for the sort of clear and unambiguous reference to entities on the side of the patient that is needed in order to avoid these confusions in the future. (shrink)

The objective of this paper is to refute the widely held view that in the wake of his so-called reistic turn Brentano subjected his notion of intentionality to a deep-going revision, viz., that he turned from an ontological account of the intentional object by way of identifying it with the thought-of-thing, i.e., the intentional correlate, or by way of attributing to it a peculiar sort of existence, to a non-ontological account thereof. It will be shown that neither the pre-reistic Brentano (...) espoused anything of an ontological account of the intentional object in that he both distinguished it sharply from the intentional correlate and definitely rejected the idea of there being different sorts of existence, and it will be argued that the apparently ineradicable inclination to ascribe to the pre-reistic Brentano an ontological account of the intentional object stems from ignoring the Aristotelian background of Brentano's thinking about relations. (shrink)

We performed a qualitative analysis of the Thesaurus in order to assess its conformity with principles of good practice in terminology and ontology design. We used both the on-line browsable version of the Thesaurus and its OWL-representation (version 04.08b, released on August 2, 2004), measuring each in light of the requirements put forward in relevant ISO terminology standards and in light of ontological principles advanced in the recent literature. Version 04.08b of the NCI Thesaurus suffers from the same broad range (...) of problems that have been observed in other biomedical terminologies. For its further development, we recommend the use of a more principled approach that allows the Thesaurus to be tested not just for internal consistency but also for its degree of correspondence to that part of reality which it is designed to represent. (shrink)

„Luhmann meets Nietzsche“ – Luhmann hat in seinem Werk jeden Anschein vermieden, mit Nietzsche zu tun zu haben. Das hatte Folgen: Bis heute scheut Nietzsche, wer Luhmann kennt, und auch wer Nietzsche kennt, scheut Luhmann. Ihre Orientierungen scheinen füreinander abwegig zu sein: Philosophie hier, Soziologie dort, hier aphoristischer und bilderreicher Stil, dort hoch komplexe, konsequent gepflegte Theorie und zwischen beiden ein Jahrhundert, das die Welt von Grund auf verändert hat. Doch Luhmann könnte für das 21. Jahrhundert entfaltet haben, was Nietzsche (...) im 19. Jahrhundert gedacht hat. Seine soziologische Systemtheorie bewegt sich in philosophischen Dimensionen, und Nietzsche hatte bereits soziologische Perspektiven auf die Gesellschaft entwickelt, die Soziologen vom Fach bald dankbar aufgenommen haben. Nietzsche und Luhmann zusammen lassen mit ihren radikal neuen Ansätzen die meisten Philosophien und Soziologien des 20. Jahrhunderts buchstäblich alt aussehen. Sie könnten Wegbereiter einer Philosophie für das 21. Jahrhundert sein, für eine gelassene Orientierung im verstörenden Nihilismus. Wenn man sie einander begegnen lässt. (shrink)

DieVorlesung über Moralphilosophie aus den 1770er Jahren ist eine wichtige Erläuterung und Ergänzung zur Grundlegung der Metaphysik der Sittenvon 1785. Die Neuedition der so genannten Menzer-Vorlesung präsentiert diese Vorlesung auf dem aktuellen Stand der Forschung. Zugrunde gelegt ist die Nachschrift Kaehler, die seit 1997 zum Kant-Archiv in Marburg gehört. Abgeglichen ist der Text mit mehreren Handschriften des Archivs der Berlin-Bandenburgischen Akademie der Wissenschaften und der Staatsbibliothek Berlin. Ein Anhang mit textkritischem Apparat und Erläuterungen zu Literatur und Personen sowie eine Einleitung (...) von Manfred Kühn erschließen die Vorlesung für alle, die sich für die Kant'sche Philosophie der Ethik interessieren. (shrink)

Electronic Health Records (EHRs) are organized around two kinds of statements: those reporting observations made, and those reporting acts performed. In neither case does the record involve any direct reference to what such statements are actually about. They record not: what is happening on the side of the patient, but rather: what is said about what is happening. While the need for a unique patient identifier is generally recognized, we argue that we should now move to an EHR regime in (...) which all clinically salient particulars – from the concrete disorder on the side of the patient and the body parts in which it occurs to the concrete treatments given – should be uniquely identified. This will allow us to achieve interoperability among different systems of records at the level where it really matters: in regard to what is happening in the real world. It will also allow us to keep track of particular disorders and of the effects of particular treatments in a precise and unambiguous way. We discuss the ontological and epistemological aspects of our claim and describe a scenario for implementation within EHR systems. (shrink)

Es wird versucht, einige Aspekte von Carnaps Werk Der logische Auflyau der Welt vor dem Hintergrund des Kantianismus zu betrachten, insbesondere die Strukturalismusthese, das Verhältnis von Gegebenem und Konstruiertem und den Wirklichkeitsbegriff; das Ergebnis geht dahin, daß sich mehr Gemeinsamkeiten mit der kantianischen Tradition zeigen als es von einem klassischen Werk des Neopositivismus zu erwarten wäre.

The paradigm of referent tracking is based on a realist presupposition which rejects so-called negative entities (congenital absent nipple, and the like) as spurious. How, then, can a referent tracking-based Electronic Health Record deal with what are standardly called ‘negative findings’? To answer this question we carried out an analysis of some 748 sentences drawn from patient charts and containing some form of negation. Our analysis shows that to deal with these sentences we need to introduce a new ontological relationship (...) between a particular and a universal, which holds when no instance of the universal has a specific qualified ontological relation with the particular. This relation is found to be able to accommodate nearly all occurrences of negative findings in the examined sample, in ways which involve no reference to negative entities. (shrink)

The goal of the OBO (Open Biomedical Ontologies) Foundry initiative is to create and maintain an evolving collection of non-overlapping interoperable ontologies that will offer unambiguous representations of the types of entities in biological and biomedical reality. These ontologies are designed to serve non-redundant annotation of data and scientific text. To achieve these ends, the Foundry imposes strict requirements upon the ontologies eligible for inclusion. While these requirements are not met by most existing biomedical terminologies, the latter may nonetheless support (...) the Foundry’s goal of consistent and non-redundant annotation if appropriate mappings of data annotated with their aid can be achieved. To construct such mappings in reliable fashion, however, it is necessary to analyze terminological resources from an ontologically realistic perspective in such a way as to identify the exact import of the ‘concepts’ and associated terms which they contain. We propose a framework for such analysis that is designed to maximize the degree to which legacy terminologies and the data coded with their aid can be successfully used for information-driven clinical and translational research. (shrink)

Affective congruency effects in the evaluation task can be explained by either spreading of activation or response competition. Eliminating effects of response compatibility by using other tasks (semantic categorisation, naming task) typically also eliminates affective congruency effects. However, there is no need for processing the affective information of the stimuli in these tasks either, which could be necessary for an affectively mediated spreading of activation (Spruyt et al., 2007, 2009, 2012). We introduced a new task to further test this hypothesis. (...) The valent/neutral-categorisation task does not confound affective congruency with response compatibility, but still requires a processing of the stimuli's valence. No affective congruency effect was obtained with this task in two experiments, disfavouring a conditional spreading activation account. On the other hand, a significant priming effect was found for associated word pairs in Experiment 1, providing evidence for the sensitivity of the task to detect spreading activation processes. (shrink)

This is the second of two articles in which I reflect on “generalized Darwinism” as currently discussed in evolutionary economics. In the companion article (Callebaut, Biol Theory 6. doi: 10.1007/s13752-013-0086-2, 2011, this issue) I approached evolutionary economics from the naturalistic perspectives of evolutionary epistemology and the philosophy of biology, contrasted evolutionary economists’ cautious generalizations of Darwinism with “imperialistic” proposals to unify the behavioral sciences, and discussed the continued resistance to biological ideas in the social sciences. Here I assess Generalized Darwinism (...) as propounded by Geoffrey Hodgson, Thorbjørn Knudsen, and others, concentrating on the roles of theory and model building in science (and the roles of analogy and metaphor therein), generative replication, and the relation between selection and self-organization. I then point to advances in current biology that promise to be more fruitful as sources of inspiration for evolutionary economics than the project to generalize Darwinism in its current, “hardened Modern Synthesis” form; and I draw some conclusions. (shrink)

Review text: "Aufs Ganze besehen präsentiert St. einen ambitionierten Entwurf, der Verschiedenstes auf eine Kernstruktur zu beziehen vermag. Vieles ist bedenkenswert und bietet Anlass, über Grundsätzliches und weitgespannte Zusammenhänge nachzusinnen."Stefan Berg in: Zeitschrift für evangelische Ethik 2/2010 "Ein stattlicher Band von einem renommierten Verlag... "In: Neue Zürcher Zeitung, 29.9.2008.

Es wird versucht, einige Aspekte von Carnaps Werk Der logische Auflyau der Welt vor dem Hintergrund des Kantianismus zu betrachten, insbesondere die Strukturalismusthese, das Verhältnis von Gegebenem und Konstruiertem und den Wirklichkeitsbegriff; das Ergebnis geht dahin, daß sich mehr Gemeinsamkeiten mit der kantianischen Tradition zeigen als es von einem klassischen Werk des Neopositivismus zu erwarten wäre.

Der exponierte erste Aphorismus des lezten Teils von Ecce Homo ist einer der herausforderndsten und erschreckendsten in Nietzsches Werk. Er handelt im Kern von der "Umwerthung aller Werthe" alst einem "Akt höchster Selbstbesinnung der Menschheit", der Nietzche zum Schicksal geworden sei und durch den er nun zum Schicksal für die Philosophie und die Menschheit werde. Der Aphorismus galt vielen als Belag dafür, dass Nietzsches Wahnsinn bereits ausgebrochen sei: als Größenwahnsinn. Doch Ecce Homo lässt in seiner klaren und konsequenten Anlage so (...) wenig wie Der Antichrist, den es vorbereiten sollte, Zeichen der Verwirrung erkennen, und Nietzsche had auch früher schon herausfordernd von seiner Aufgabe gesprochen: als Einzelner die Menschheit und die Kultur auf eine neue Stufe zu heen. man wird Nietzsches Werk nur angemessen verstehen können, wenn man auch diesem Aphorismus seinen Ort in ihm geben kann. Die folgende Abhandlung versucht ein kontextuelle Interpretation des Aphorismus: eine Interpretation aus seinem eigenen Kontext, dem Kontext von Ecce Homo und Der Antichrist und dem Kontext von Nietzches Werk im ganzen.The first aphorism of the last chapter of Ecce Homo is oen of the most challenging and terrifying in Nietzsche's work. It essentially deals with the "reevaluation of all values" as an "act of the highest self-assessment of humanity" for which Nietzsche was fated and through which he would become a destiny for philosophy and humanity. The aphorism has served as evidence to some that Nietzsche's madness had already broken out - as megalomania. Yet the clear and careful construction of Ecce Homo, like The Antichrist for which it was supposed to pave the way, do not show any signs of confusion. And Nietzshe had already spoken of his task in a challenging manner: to raise humanity and culture to a new level as a single individual. Correctly understanding Nietzsche requires being able to integrate this aphorism into this work, too. The following essay provides an interpretation of this aphorism based on the context of Ecce Homo and The Antichrist as well as against the background of Nietzsche's work as a whole. (shrink)